Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.
Identifieur interne : 001541 ( Main/Exploration ); précédent : 001540; suivant : 001542Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.
Auteurs : Nicole D. Powell [États-Unis] ; Jacqueline W. Mays ; Michael T. Bailey ; Mark L. Hanke ; John F. SheridanSource :
- Brain, behavior, and immunity [ 1090-2139 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Cellules dendritiques (immunologie), Comportement compétitif (physiologie), Cytométrie en flux, Domination sociale, Environnement social, Immunité acquise (immunologie), Interféron alpha (biosynthèse), Interféron gamma (biosynthèse), Lymphocytes T CD8+ (immunologie), Mâle, Mémoire immunologique, Numération cellulaire, RT-PCR, Souris, Souris de lignée C57BL, Stress psychologique (immunologie), Virus de la grippe A (immunologie), Épitopes (immunologie).
- MESH :
- biosynthèse : Interféron alpha, Interféron gamma.
- immunologie : Antigènes viraux, Cellules dendritiques, Immunité acquise, Lymphocytes T CD8+, Stress psychologique, Virus de la grippe A, Épitopes.
- physiologie : Comportement compétitif.
- Animaux, Cytométrie en flux, Domination sociale, Environnement social, Mâle, Mémoire immunologique, Numération cellulaire, RT-PCR, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Adaptive Immunity (immunology), Animals, Antigens, Viral (immunology), CD11 Antigens (immunology), CD8-Positive T-Lymphocytes (immunology), Cell Count, Competitive Behavior (physiology), Dendritic Cells (immunology), Epitopes (immunology), Flow Cytometry, Immunologic Memory, Influenza A virus (immunology), Interferon-alpha (biosynthesis), Interferon-gamma (biosynthesis), Male, Mice, Mice, Inbred C57BL, Reverse Transcriptase Polymerase Chain Reaction, Social Dominance, Social Environment, Stress, Psychological (immunology).
- MESH :
- chemical , biosynthesis : Interferon-alpha, Interferon-gamma.
- chemical , immunology : Antigens, Viral, CD11 Antigens, Epitopes.
- immunology : Adaptive Immunity, CD8-Positive T-Lymphocytes, Dendritic Cells, Influenza A virus, Stress, Psychological.
- physiology : Competitive Behavior.
- Animals, Cell Count, Flow Cytometry, Immunologic Memory, Male, Mice, Mice, Inbred C57BL, Reverse Transcriptase Polymerase Chain Reaction, Social Dominance, Social Environment.
Abstract
Dendritic cells (DCs) sample their surrounding microenvironment and consequently send immunogenic or regulatory signals to T cells during DC/T cell interactions, shaping the primary adaptive immune response to infection. The microenvironment resulting from repeated social defeat increases DC co-stimulatory molecule expression and primes DCs for enhanced cytokine responses in vitro. In this study, we show that social disruption stress (SDR) results in the generation of immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the adoptive transfer of DCs from SDR mice had significantly increased numbers of D(b)NP(366-74)CD8(+) T cells, increased IFN-γ and IFN-α mRNA, and decreased influenza M1 mRNA expression in the lung during the peak primary response (9 days post-infection), compared to mice that received DCs from naïve mice. These data demonstrate that repeated social defeat is a significant environmental influence on immunogenic DC activation and function.
DOI: 10.1016/j.bbi.2010.07.243
PubMed: 20656014
Affiliations:
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Powell</name><affiliation wicri:level="2"><nlm:affiliation>Section of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH, USA. Nicole.Powell@osumc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Mays, Jacqueline W" sort="Mays, Jacqueline W" uniqKey="Mays J" first="Jacqueline W" last="Mays">Jacqueline W. Mays</name></author><author><name sortKey="Bailey, Michael T" sort="Bailey, Michael T" uniqKey="Bailey M" first="Michael T" last="Bailey">Michael T. Bailey</name></author><author><name sortKey="Hanke, Mark L" sort="Hanke, Mark L" uniqKey="Hanke M" first="Mark L" last="Hanke">Mark L. Hanke</name></author><author><name sortKey="Sheridan, John F" sort="Sheridan, John F" uniqKey="Sheridan J" first="John F" last="Sheridan">John F. Sheridan</name></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="eISSN">1090-2139</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity (immunology)</term><term>Animals</term><term>Antigens, Viral (immunology)</term><term>CD11 Antigens (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Cell Count</term><term>Competitive Behavior (physiology)</term><term>Dendritic Cells (immunology)</term><term>Epitopes (immunology)</term><term>Flow Cytometry</term><term>Immunologic Memory</term><term>Influenza A virus (immunology)</term><term>Interferon-alpha (biosynthesis)</term><term>Interferon-gamma (biosynthesis)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Social Dominance</term><term>Social Environment</term><term>Stress, Psychological (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Cellules dendritiques (immunologie)</term><term>Comportement compétitif (physiologie)</term><term>Cytométrie en flux</term><term>Domination sociale</term><term>Environnement social</term><term>Immunité acquise (immunologie)</term><term>Interféron alpha (biosynthèse)</term><term>Interféron gamma (biosynthèse)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mâle</term><term>Mémoire immunologique</term><term>Numération cellulaire</term><term>RT-PCR</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Stress psychologique (immunologie)</term><term>Virus de la grippe A (immunologie)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-alpha</term><term>Interferon-gamma</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>CD11 Antigens</term><term>Epitopes</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron alpha</term><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Cellules dendritiques</term><term>Immunité acquise</term><term>Lymphocytes T CD8+</term><term>Stress psychologique</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adaptive Immunity</term><term>CD8-Positive T-Lymphocytes</term><term>Dendritic Cells</term><term>Influenza A virus</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Comportement compétitif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Competitive Behavior</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Flow Cytometry</term><term>Immunologic Memory</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Social Dominance</term><term>Social Environment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cytométrie en flux</term><term>Domination sociale</term><term>Environnement social</term><term>Mâle</term><term>Mémoire immunologique</term><term>Numération cellulaire</term><term>RT-PCR</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dendritic cells (DCs) sample their surrounding microenvironment and consequently send immunogenic or regulatory signals to T cells during DC/T cell interactions, shaping the primary adaptive immune response to infection. The microenvironment resulting from repeated social defeat increases DC co-stimulatory molecule expression and primes DCs for enhanced cytokine responses in vitro. In this study, we show that social disruption stress (SDR) results in the generation of immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the adoptive transfer of DCs from SDR mice had significantly increased numbers of D(b)NP(366-74)CD8(+) T cells, increased IFN-γ and IFN-α mRNA, and decreased influenza M1 mRNA expression in the lung during the peak primary response (9 days post-infection), compared to mice that received DCs from naïve mice. These data demonstrate that repeated social defeat is a significant environmental influence on immunogenic DC activation and function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Bailey, Michael T" sort="Bailey, Michael T" uniqKey="Bailey M" first="Michael T" last="Bailey">Michael T. Bailey</name><name sortKey="Hanke, Mark L" sort="Hanke, Mark L" uniqKey="Hanke M" first="Mark L" last="Hanke">Mark L. Hanke</name><name sortKey="Mays, Jacqueline W" sort="Mays, Jacqueline W" uniqKey="Mays J" first="Jacqueline W" last="Mays">Jacqueline W. Mays</name><name sortKey="Sheridan, John F" sort="Sheridan, John F" uniqKey="Sheridan J" first="John F" last="Sheridan">John F. Sheridan</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Powell, Nicole D" sort="Powell, Nicole D" uniqKey="Powell N" first="Nicole D" last="Powell">Nicole D. 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